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RESEARCH PAPERS
Cell-supracellular structural relations solve the French Flag Problem without graded molecular control
bioRxiv 2025
Clint S. Ko, Ruonan Chen, Nina Magid, Katherine Courtemanche, Pearson W. Miller, Alan R. Rodrigues, Amy E. Shyer
Morphogens enable interacting supracellular phases that generate organ architecture
Science 2023
Sichen Yang, Karl H. Palmquist, Levy Nathan, Charlotte R. Pfeifer, Paula J. Schultheiss, Anurag Sharma, Lance C. Kam, Pearson W. Miller, Amy E. Shyer, Alan R. Rodrigues
Press Coverage
Reciprocal cell-ECM dynamics generate supracellular fluidity underlying spontaneous follicle patterning
Cell 2022
Karl H. Palmquist, Sydney F. Tiemann, Farrah L. Ezzeddine, Sichen Yang, Charlotte R. Pfeifer, Anna Erzberger, Alan R. Rodrigues, Amy E. Shyer
Press Coverage
Emergent cellular self-organization and mechanosensation initiate follicle pattern in the avian skin
Science 2017
Amy E. Shyer, Alan R. Rodrigues, Grant G. Schroeder, Elena Kassianidou, Sanjay Kumar, Richard M. Harland
Press Coverage
CONCEPTUAL PAPERS
Epigenetics beyond the cell: Supracellular organization of fate and form in morphogenesis
Cold Spring Harb Perspect Biol. 2025
Rubens Sautchuk Jr, Sichen Yang, Amy E. Shyer, Alan R. Rodrigues
Transcending the hegemony of the molecular machine through an organic renewal of biology and biomedicine
Cells & Development 2025
Amy E. Shyer & Alan R. Rodrigues
Biological theories of morphogenesis based on holistic biophysical thinking
Biological Theory 2024
Karl H. Palmquist, Clint S. Ko, Amy E. Shyer, Alan R. Rodrigues
Creative processes during vertebrate organ morphogenesis: Biophysical self-organization at the supracellular scale
Current Opinion in Cell Biology 2024
Charlotte R. Pfeifer, Amy E. Shyer, Alan R. Rodrigues
The role of mechanics in a ‘post-molecular’ conception of morphogenesis
Phys Biology 2021
Alan R. Rodrigues & Amy E. Shyer in Lenne et al.
OPINIONS & INTERVIEWS
Interviewed for biophysics perspective in Quanta Magazine
Genes have harnessed physics to help grow living things, Anna Demming, Quanta Magazine 2025
Interviewed for opinion essay in the New York Times
What Kennedy gets right about the chemicals in our food, Julia Belluz, The New York Times 2025
Mechanobiology of the supracellular in Cell
Mechanobiology: Shaping the future of cellular form and function, Cell 2024
Interviewed in Technology Feature in Nature
Push and Pull: How to measure the forces that sculpt embryos, Michael Eisenstein, Nature 2024
Interviewed in New Feature in Nature
The secret forces that squeeze and pull life into shape, Amber Dance, Nature 2021